P-bodies.html



Processing bodies (also called GW or Dcp bodies) are regions within the cytoplasm of the eukaryotic cell consisting of many enzymes involved in mRNA turnover. P bodies are likely the site of miRNA action, as miRNA-targeted mRNAs are recruited to P bodies and degraded or sequestered from translational machinery.

The following activities of p-bodies were demonstrated:

• degrade unwanted mRNAs that lack a 5' cap
• store mRNA until needed for translation
• aid in translational repression by miRNAs (related to siRNAs)

New evidence by Hoyle et al suggests a novel site termed EGP bodies may be responsible for mRNA storage as these sites lack the decapping enzyme.¹

References

1. ^ Hoyle et al, 2007. Stress dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies. Journal of Cell Biology. 179,1,65-74

• Jean Marx (2005-11-04). ""P-Bodies Mark the Spot for Controlling Protein Production."". Science magazine. Retrieved on 2006-09-10.

Further reading

• Eulalio, Ana.; Behm-Ansmant, Isabelle. Izaurralde, Elisa. (January 2007). "P bodies: at the crossroads of post-transcriptional pathways". Nat Rev Mol Cell Biol 8 (1): 9-22, http://dx.doi.org/10.1038/nrm2080. 

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